Lyrica: Uses, Taking, Side Effects, Warnings - (2024)

What is Lyrica?

Lyrica is a prescription medicine used in adults, 18 years of age and older to treat:

  • pain from damaged nerves (neuropathic pain) that happens with diabetes
  • pain from damaged nerves (neuropathic pain) that follows healing of shingles
  • fibromyalgia (pain all over your body)
  • pain from damaged nerves (neuropathic pain) that follows spinal cord injury

It is not known if Lyrica is safe and effective in people under 18 years of age for the treatment of fibromyalgia and neuropathic pain with diabetes, shingles, or spinal cord injury.

Lyrica is a prescription medicine used in people 1 month of age and older to treat:

  • partial-onset seizures when taken together with other seizure medicines.

For the treatment of partial-onset seizures when taken together with other seizure medicines, it is not known if Lyrica is safe and effective in children under 1 month of age.

What is the most important information I should know about Lyrica?

Lyrica may cause serious side effects including:

  • serious, even life-threatening, allergic reactions
  • suicidal thoughts or actions
  • serious breathing problems
  • swelling of your hands, legs and feet
  • dizziness and sleepiness

These serious side effects are described below:

  • Serious, even life-threatening, allergic reactions.
    Stop taking Lyrica and call your healthcare provider right away if you have any of these signs of a serious allergic reaction:
    • swelling of your face, mouth, lips, gums, tongue, throat or neck
    • trouble breathing
    • rash, hives (raised bumps) or blisters
  • Like other antiepileptic drugs, Lyrica may cause suicidal thoughts or actions in a very small number of people, about 1 in 500. Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:
    • thoughts about suicide or dying
    • attempts to commit suicide
    • new or worse depression
    • new or worse anxiety
    • feeling agitated or restless
    • panic attacks
    • trouble sleeping (insomnia)
    • new or worse irritability
    • acting aggressive, being angry, or violent
    • acting on dangerous impulses
    • an extreme increase in activity and talking (mania)
    • other unusual changes in behavior or mood

      If you have suicidal thoughts or actions, do not stop Lyrica without first talking to a healthcare provider.

    • Stopping Lyrica suddenly can cause serious problems.
    • Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

      ​​​​​​​How can I watch for early symptoms of suicidal thoughts and actions?

    • Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.
    • Keep all follow-up visits with your healthcare provider as scheduled.
    • Call your healthcare provider between visits as needed, especially if you are worried about symptoms.
  • Serious breathing problems can occur when Lyrica is taken with other medicines that can cause severe sleepiness or decreased awareness, or when it is taken by someone who already has breathing problems. Watch for increased sleepiness or decreased breathing when starting Lyrica or when the dose is increased. Get help right away if breathing problems occur.
  • Swelling of your hands, legs and feet. This swelling can be a serious problem for people with heart problems.
  • Dizziness and sleepiness. Do not drive a car, work with machines, or do other dangerous activities until you know how Lyrica affects you. Ask your healthcare provider about when it will be okay to do these activities.

Who should not take Lyrica?

Do not take Lyrica if you are allergic to pregabalin or any of the ingredients in Lyrica.

See "What is the most important information I should know about Lyrica?" above for the signs of an allergic reaction.

See the end of this Medication Guide for a complete list of ingredients in Lyrica.

What should I tell my healthcare provider before taking Lyrica?

Before taking Lyrica, tell your healthcare provider about all your medical conditions, including if you:

  • have or have had depression, mood problems or suicidal thoughts or behavior.
  • have kidney problems or get kidney dialysis.
  • have heart problems including heart failure.
  • have a bleeding problem or a low blood platelet count.
  • have abused prescription medicines, street drugs, or alcohol in the past.
  • have ever had swelling of your face, mouth, tongue, lips, gums, neck, or throat (angioedema).
  • plan to father a child. Animal studies have shown that pregabalin, the active ingredient in Lyrica, made male animals less fertile and caused sperm to change. Also, in animal studies, birth defects were seen in the offspring (babies) of male animals treated with pregabalin. It is not known if these problems can happen in people who take Lyrica.
  • are pregnant or plan to become pregnant. Lyrica may harm your unborn baby. You and your healthcare provider will decide if you should take Lyrica while you are pregnant.
    • If you become pregnant while taking Lyrica, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy. Information about the registry can also be found at the website,
  • Are breastfeeding or plan to breastfeed. Lyrica passes into your breast milk. It is not known if Lyrica can harm your baby. Talk to your healthcare provider about the best way to feed your baby if you take Lyrica. Breastfeeding is not recommended while taking Lyrica.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements. Lyrica and other medicines may affect each other causing side effects.

Especially tell your healthcare provider if you take:

  • angiotensin converting enzyme (ACE) inhibitors, which are used to treat many conditions, including high blood pressure. You may have a higher chance for swelling and hives if these medicines are taken with Lyrica.
  • Avandia (rosiglitazone) or Actos (pioglitazone) for diabetes. You may have a higher chance of weight gain or swelling of your hands or feet if these medicines are taken with Lyrica.
  • any opioid pain medicine (such as oxycodone), or medicines for anxiety (such as lorazepam) or insomnia (such as zolpidem). You may have a higher chance for dizziness, sleepiness or serious breathing problems if these medicines are taken with Lyrica.
  • any medicines that make you sleepy.

Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist each time you get a new medicine. Do not start a new medicine without talking with your healthcare provider.

How should I take Lyrica?

  • Take Lyrica exactly as prescribed. Your healthcare provider will tell you how much Lyrica to take and when to take it.
  • Lyrica may be taken with or without food.
  • Your healthcare provider may change your dose. Do not change your dose without talking to your healthcare provider.
  • Do not stop taking Lyrica without talking to your healthcare provider. If you stop taking Lyrica suddenly you may have headaches, nausea, diarrhea, trouble sleeping, increased sweating, or you may feel anxious. If you have epilepsy and you stop taking Lyrica suddenly, you may have seizures more often. Talk with your healthcare provider about how to stop Lyrica slowly.
  • If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, just skip the missed dose. Take the next dose at your regular time. Do not take 2 doses at the same time.
  • If you take too much Lyrica, call your healthcare provider or poison control center, or go to the nearest emergency room right away.

What should I avoid while taking Lyrica?

  • Do not drive a car, work with machines, or do other dangerous activities until you know how Lyrica affects you.
  • Do not drink alcohol while taking Lyrica. Lyrica and alcohol can affect each other and increase side effects such as sleepiness and dizziness.

What are the possible side effects of Lyrica?

Lyrica may cause serious side effects, including:

  • See "What is the most important information I should know about Lyrica?"
  • Muscle problems, muscle pain, soreness, or weakness. If you have these symptoms, especially if you feel sick and have a fever, tell your healthcare provider right away.
  • Problems with your eyesight, including blurry vision. Call your healthcare provider if you have any changes in your eyesight.
  • Weight gain. If you have diabetes, weight gain may affect the management of your diabetes. Weight gain can also be a serious problem for people with heart problems.
  • Feeling "high".

The most common side effects of Lyrica in adults are:

  • dizziness
  • blurry vision
  • dry mouth
  • weight gain
  • sleepiness
  • trouble concentrating
  • swelling of hands and feet

The most common side effects of Lyrica in children are weight gain, increase in appetite, and sleepiness.

Lyrica caused skin sores in animal studies. Skin sores did not happen in studies in people. If you have diabetes, you should pay attention to your skin while taking Lyrica and tell your healthcare provider about any sores or skin problems.

Tell your healthcare provider about any side effect that bothers you or that does not go away.

These are not all the possible side effects of Lyrica. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Lyrica Images

  • Lyrica 25 mg
  • Lyrica 50 mg
  • Lyrica 100 mg
  • Lyrica 150 mg
  • Lyrica 200 mg

Drug Interactions

A total of 283 medications are known to interact withLyrica. Use the Interactions Checker Tool.

Common Interactions Checks

  • atorvastatin
  • baclofen
  • Cymbalta
  • gabapentin
  • levothyroxine
  • lisinopril
  • metformin
  • omeprazole
  • oxycodone
  • tramadol
  • trazodone
  • Vitamin D3

General information about the safe and effective use of Lyrica

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Lyrica for a condition for which it was not prescribed. Do not give Lyrica to other people, even if they have the same symptoms you have. It may harm them. You can ask your healthcare provider or pharmacist for information about Lyrica that is written for health professionals.

How should I store Lyrica?

  • Store Lyrica capsules and oral solution at room temperature between 68°F to 77°F (20°C to 25°C) in its original package.
  • Safely throw away any Lyrica that is out of date or no longer needed.

Keep Lyrica and all medicines out of the reach of children.

What are the ingredients in Lyrica?

Active ingredient: pregabalin

Inactive ingredients:

Capsules: lactose monohydrate, cornstarch, talc

Capsule shell: gelatin and titanium dioxide; Orange capsule shell: red iron oxide; White capsule shell: sodium lauryl sulfate, colloidal silicon dioxide. Colloidal silicon dioxide is a manufacturing aid that may or may not be present in the capsule shells.

Imprinting ink: shellac, black iron oxide, propylene glycol, potassium hydroxide.

Oral solution: methylparaben, propylparaben, monobasic sodium phosphate anhydrous, dibasic sodium phosphate anhydrous, sucralose, artificial strawberry #11545 and purified water.

You can also visit the Lyrica website at or call 1-866-459-7422 (1-866-4LYRICA).

Source: National Library of Medicine. Last updated April 3, 2020.

Lyrica: Uses, Taking, Side Effects, Warnings - (2024)


Is pregabalin good or bad for you? ›

Pregabalin has beneficial effects on some symptoms of neuropathic pain. However, its use significantly increases the risk of a number of adverse events and discontinuation due to adverse events.

What is the strongest drug for nerve pain? ›

Anticonvulsants are one of the most effective medications for treating nerve pain. Examples include pregabalin (Lyrica) and gabapentin (Neurontin). These medications are typically very effective in treating nerve pain, but they may also cause undesired side effects, such as: lethargy.

What does pregabalin do to your heart? ›

Introduction: Pregabalin, a structural analog to λ-aminobutyric acid, is prescribed for neurological disorders. Through actions to cause sodium/water retention, the agent may increase the risk of acute heart failure (AHF).

What happens if you take pregabalin? ›

Pregabalin is often used for epilepsy, but you can also take it to help with pain or anxiety if you do not have epilepsy. It takes at least a few weeks for pregabalin to work. The side effects of pregabalin are usually mild and go away by themselves. The most common ones are feeling sleepy, dizziness and headaches.

Is Lyrica hard on the liver? ›

Conclusion: Pregabalin abuse can markedly affect the liver on both levels, biochemically and histopathologically Keywords: Pregabalin, Liver, Van kupffer cells.

Is pregabalin safe for the elderly? ›

Geriatric. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of pregabalin in the elderly.

What stops nerve pain immediately? ›

Painkillers. For severe nerve pain, powerful opioid painkillers can help. Studies have found that for many types of nerve pain, they are as effective as anticonvulsants or antidepressants. Unlike other treatments for nerve pain, they also work very quickly.

What is the best medication for nerve pain in the elderly? ›

Serotonin-norepinephrine reuptake inhibitors (SNRIs): SNRIs such as venlafaxine and duloxetine can be used for neuropathic pain in the elderly. SNRIs are generally well tolerated but side effects include hyponatremia, giddiness, nausea, and abdominal pain.

What is the safest pain reliever for seniors? ›

For most older adults, the safest oral OTC painkiller for daily or frequent use is acetaminophen (brand name Tylenol), provided you are careful to not exceed a total dose of 3,000mg per day.

How long is it safe to take pregabalin? ›

Some people will get benefit at this dose but others may require a higher dose. The dose can be increased gradually to a maximum of 300mg twice a day. How long should I take pregabalin for? In general, pregabalin will have to be taken for as long as you are requiring nerve pain relief.

Can pregabalin cause stroke? ›

In patients prescribed pregabalin, the highest risk was observed for deep venous thrombosis (HR: 1.57, 95% CI 1.31–1.88), followed by peripheral vascular disease (HR: 1.35, 95% CI 1.22–1.49), myocardial infarction (HR: 1.29, 95% CI 1.13–1.47), pulmonary embolism (HR: 1.28, 95% CI 1.04–1.59), stroke (HR: 1.26, 95% CI ...

Is pregabalin 75 mg safe? ›

Pregabalin can cause a severe allergic reaction.

Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor. If you have diabetes or heart problems, call your doctor if you have weight gain or swelling in your hands or feet while taking pregabalin.

How much pregabalin is too much? ›

There are both mental and physical symptoms that occur when someone is overdosing from Lyrica, and the risk for an overdose is increased when mixing Lyrica with other drugs. The recommended maximum dosage for Lyrica is no more than 600 milligrams per day. Taking more than this can lead to lethal outcomes.

What is the street name for pregabalin? ›

'Budweisers' and 'Buds' are common street names for Pregabalin, supposedly because some 300mg capsules are red and white in colour and their effect is a bit like alcohol. Other street names include 'Fizers'.

Is pregabalin safe for kidneys? ›

Pregabalin may reduce kidney function and can cause kidney failure. If you notice any signs of your kidneys not working well, such as decreased amounts of urine being produced, swelling of the legs and ankles, difficulty urinating, or an increased need to urinate at night, contact your doctor as soon as possible.

Is pregabalin safe long term? ›

Pregabalin oral capsule is used for long-term treatment. It comes with serious risks if you don't take it as prescribed. If you stop taking the drug suddenly or don't take it at all: If you don't take pregabalin or stop taking it, your pain or seizures won't go away or may get worse.

Is pregabalin hard on the liver? ›

Since its approval and more wide scale use, however, pregabalin has been linked to rare instances of clinically apparent liver injury. Most cases were mild and frequently without jaundice.


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